Targeting the Shikimate Pathway in the Malaria Parasite Plasmodium falciparum | Zendy

Glenn A. McConkey | Zendy

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Targeting the Shikimate Pathway in the Malaria Parasite Plasmodium falciparum

Author(s) -

Glenn A. McConkey

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.1.175

Subject(s) - shikimate pathway , shikimic acid , plasmodium falciparum , malaria , biology , biochemistry , plasmodium berghei , aromatic amino acids , amino acid , immunology

The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.

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