Experimental Evaluation of Second-Line Oral Treatments of Visceral Leishmaniasis Caused by Leishmania infantum | Zendy

JeanPierre Gangneux | Zendy; Michael Dullin | Zendy; Annie Sulahian | Zendy; Yves JeanFrançois Garin | Zendy; Francis Derouin | Zendy

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Experimental Evaluation of Second-Line Oral Treatments of Visceral Leishmaniasis Caused by Leishmania infantum

Author(s) -

JeanPierre Gangneux,

Michael Dullin,

Annie Sulahian,

Yves JeanFrançois Garin,

Francis Derouin

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.1.172

Subject(s) - leishmania infantum , visceral leishmaniasis , leishmaniasis , leishmania , virology , second line , medicine , biology , immunology , first line , parasite hosting , computer science , world wide web

In a murine model of Leishmania infantum visceral leishmaniasis, metronidazole, ketoconazole, fluconazole, itraconazole, and terbinafine were less effective than antimonial agents in reducing hepatic parasite load. Ketoconazole potentiated the effect of meglumine antimoniate reference therapy through its marked activity against spleen infection.

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