Increase in Quinolone Resistance in a Haemophilus influenzae Strain Isolated from a Patient with Recurrent Respiratory Infections Treated with Ofloxacin | Zendy

Jordi Vilà | Zendy; Joaquı́m Ruiz | Zendy; F Sánchez | Zendy; Ferrán Navarro | Zendy; Beatriz Mirelis | Zendy; M. Teresa Jiménez de Anta | Zendy; Guillem Prats | Zendy

Open Access

Increase in Quinolone Resistance in a Haemophilus influenzae Strain Isolated from a Patient with Recurrent Respiratory Infections Treated with Ofloxacin

Author(s) -

Jordi Vilà,

Joaquı́m Ruiz,

F Sánchez,

Ferrán Navarro,

Beatriz Mirelis,

M. Teresa Jiménez de Anta,

Guillem Prats

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.1.161

Subject(s) - ofloxacin , ciprofloxacin , haemophilus influenzae , quinolone , microbiology and biotechnology , haemophilus , pasteurellaceae , respiratory tract infections , drug resistance , antibacterial agent , medicine , virology , respiratory system , antibiotics , biology , bacteria , genetics

The increase in the level of quinolone resistance of Haemophilus influenzae clinical isolates during ofloxacin therapy of a patient with recurrent respiratory infections was investigated. The first isolate (MIC of ciprofloxacin of 2 microg/ml) and the second isolate (MIC of 32 microg/ml) belonged to the same clone, as shown by pulsed-field gel electrophoresis, and the increase in the resistance level was associated with a substitution in Ser-84 to Arg in the ParC protein. These results emphasize the potential risk of development of quinolone-resistant H. influenzae during fluoroquinolone therapy in patients with recurrent respiratory infection.

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