Open AccessSynergism between Poly-(1-6)-β- d -Glucopyranosyl-(1-3)-β d -Glucopyranose Glucan and Cefazolin in Prophylaxis of Staphylococcal Wound Infection in a Guinea Pig Model
Author(s) -
Allen B. Kaiser,
Douglas S. Kernodle
Publication year - 1998
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.42.9.2449
Subject(s) - cefazolin , glucan , microbiology and biotechnology , antibiotics , staphylococcus aureus , guinea pig , micrococcaceae , chemistry , staphylococcal infections , pharmacology , medicine , antibacterial agent , bacteria , biology , biochemistry , genetics
To determine whether the infection-preventing capability of the neutrophil-activating agent poly-(1-6)-β-d -glucopyranosyl-(1-3)-β-d -glucopyranose glucan (PGG-glucan) can be enhanced with antibiotic prophylaxis, we administered PGG-glucan and cefazolin, alone and in combination, to guinea pigs inoculated with isolates of staphylococci. Guinea pigs receiving both PGG-glucan and cefazolin had 50% infective doses that were 8- to 20-fold higher than those obtained with cefazolin alone and 100- to 200-fold higher than those obtained with PGG-glucan alone. PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.