Activity of Liposomal Amphotericin B with Prolonged Circulation in Blood versus Those of AmBisome and Fungizone against Intracellular Candida albicans in Murine Peritoneal Macrophages | Zendy

Els W. M. van Etten | Zendy; Wim van Vianen | Zendy; Janneke Hak | Zendy; Irma A. J. M. BakkerWoudenberg | Zendy

Open Access

Activity of Liposomal Amphotericin B with Prolonged Circulation in Blood versus Those of AmBisome and Fungizone against Intracellular Candida albicans in Murine Peritoneal Macrophages

Author(s) -

Els W. M. van Etten,

Wim van Vianen,

Janneke Hak,

Irma A. J. M. BakkerWoudenberg

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.9.2437

Subject(s) - candida albicans , amphotericin b , intracellular , microbiology and biotechnology , liposome , corpus albicans , pharmacology , biology , mycosis , antifungal , medicine , immunology , biochemistry

Activity against intracellular Candida albicans was assessed in C. albicans-infected murine peritoneal macrophages exposed to long-circulating pegylated amphotericin B liposomes (PEG-AMB-LIP), AmBisome, or Fungizone. The level of antifungal activity of Fungizone is much higher than that of AmBisome or PEG-AMB-LIP, while PEG-AMB-LIP and AmBisome show equivalent activity levels. Previous exposure of uninfected macrophages to PEG-AMB-LIP or AmBisome is advantageous for intracellular antifungal activity.

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