Prevalence and Characterization of the Mechanisms of Macrolide, Lincosamide, and Streptogramin Resistance in Isolates of Streptococcus pneumoniae | Zendy

Nicole Johnston | Zendy; Joyce C. de Azavedo | Zendy; James D. Kellner | Zendy; Donald E. Low | Zendy

Open Access

Prevalence and Characterization of the Mechanisms of Macrolide, Lincosamide, and Streptogramin Resistance in Isolates of Streptococcus pneumoniae

Author(s) -

Nicole Johnston,

Joyce C. de Azavedo,

James D. Kellner,

Donald E. Low

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.9.2425

Subject(s) - erythromycin , streptococcus pneumoniae , microbiology and biotechnology , clindamycin , biology , streptococcaceae , antibacterial agent , streptococcus , antibiotics , genetics , bacteria

Of a total of 147 erythromycin-resistantStreptococcus pneumoniae isolates, 64 (43.5%) were resistant to erythromycin, clindamycin, and streptogramin B (MLSB phenotype), 57 of which possessed theermB gene. Eighty-two (55.8%) were resistant to erythromycin alone (M phenotype), 81 of which possessed themefE gene. One was erythromycin and streptogramin B resistant but susceptible to clindamycin (MS phenotype) and possessed neither theerm gene nor themefE gene.

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