In Vitro Effectiveness of Povidone-Iodine on Acanthamoeba Isolates from Human Cornea | Zendy

S. Gatti | Zendy; C. Cevini | Zendy; Antonella Bruno | Zendy; Gabriella Penso | Zendy; Paolo Rama | Zendy; Massimo Scaglia | Zendy

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In Vitro Effectiveness of Povidone-Iodine on Acanthamoeba Isolates from Human Cornea

Author(s) -

S. Gatti,

C. Cevini,

Antonella Bruno,

Gabriella Penso,

Paolo Rama,

Massimo Scaglia

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.9.2232

Subject(s) - acanthamoeba , cornea , in vitro , microbiology and biotechnology , acanthamoeba keratitis , iodine , biology , medicine , chemistry , biochemistry , organic chemistry , neuroscience

Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious topical and systemic drugs. We evaluated the in vitro effectiveness of povidone-iodine (PVP-I [Betadine]), an agent with broad antibacterial and antiviral activity, compared to that of chlorhexidine (CXD), a cationic antiseptic, on Acanthamoeba isolates from patients with amebic keratitis. The results showed that PVP-I solution from 0.5 to 2.5% has a better antiamebic activity both on trophic and cystic stages of Acanthamoeba spp. than does CXD.

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