Confirmatory Evidence from 18S rRNA Gene Analysis for In Vivo Development of Propamidine Resistance in a Temporal Series of Acanthamoeba Ocular Isolates from a Patient | Zendy

Dolena R. Ledee | Zendy; D.V. Seal | Zendy; Thomas J. Byers | Zendy

Open Access

Confirmatory Evidence from 18S rRNA Gene Analysis for In Vivo Development of Propamidine Resistance in a Temporal Series of Acanthamoeba Ocular Isolates from a Patient

Author(s) -

Dolena R. Ledee,

D.V. Seal,

Thomas J. Byers

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.8.2144

Subject(s) - acanthamoeba , acanthamoeba keratitis , biology , 18s ribosomal rna , microbiology and biotechnology , gene , protozoa , ribosomal rna , virology , genetics

DNA sequences of three 18S rRNA gene alleles present in trophozoites obtained before and after therapy for Acanthamoeba keratitis substantiate a previous report that the infection was due to a single Acanthamoeba strain. Thus, the possibility that propamidine resistance which developed during therapy was due to a mixed infection was ruled out.

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