Tn 5706 , a Transposon-Like Element from Pasteurella multocida Mediating Tetracycline Resistance | Zendy

Corinna Kehrenberg | Zendy; Christiane Werckenthin | Zendy; Štefan Schwarz | Zendy

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Tn 5706 , a Transposon-Like Element from Pasteurella multocida Mediating Tetracycline Resistance

Author(s) -

Corinna Kehrenberg,

Christiane Werckenthin,

Štefan Schwarz

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.8.2116

Subject(s) - transposable element , pasteurella multocida , transposase , tetr , tetracycline , biology , microbiology and biotechnology , genetics , insertion sequence , bacteria , gene , mutant , antibiotics , repressor , transcription factor

The 4,378-bp putative tetracycline resistance transposon Tn5706 of Pasteurella multocida consists of an internal tet(H)-tetR resistance gene region which is flanked by almost identical insertion elements, IS1596 and IS1597. Two reading frames for proteins of 70 and 228 amino acids were detected in each of these insertion sequence elements. The 228-amino-acid protein revealed homology to transposase proteins of gram-positive bacteria.

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