Open AccessIn Vitro Activity of a New Ketolide Antibiotic, HMR 3647, against Chlamydia pneumoniae
Author(s) -
Patricia M. Roblin,
Margaret R. Hammerschlag
Publication year - 1998
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.42.6.1515
Subject(s) - roxithromycin , microbiology and biotechnology , azithromycin , chlamydia , biology , antibacterial agent , erythromycin , antibiotics , ketolide , pneumonia , minimum inhibitory concentration , medicine , immunology
The in vitro activities of HMR 3647, roxithromycin, erythromycin, and azithromycin against 19 strains of Chlamydia pneumoniae were tested. The MIC at which 90% of the isolates are inhibited and the minimum bactericidal concentration at which 90% of the isolates are killed of HMR 3647 were 0.25 microgram/ml (range, 0.015 to 2 micrograms/ml). Nine recently obtained clinical isolates from children with pneumonia were more susceptible (MICs, 0.015 to 0.0625 microgram/ml) than older strains that had been passaged more extensively.
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