In Vitro Activities of the New Ketolide Antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany | Zendy

Ralf René Reinert | Zendy; A. Bryskier | Zendy; Rudolf Lütticken | Zendy

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In Vitro Activities of the New Ketolide Antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany

Author(s) -

Ralf René Reinert,

A. Bryskier,

Rudolf Lütticken

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.6.1509

Subject(s) - ketolide , erythromycin , microbiology and biotechnology , telithromycin , penicillin , biology , antibiotics , streptococcus pneumoniae , agar dilution , antibacterial agent , agar dilution method , minimum inhibitory concentration

The comparative in vitro activity of HMR 3004 and HMR 3647, new ketolide antibiotics, was tested by a standard agar dilution technique against 221 pneumococcal strains, including isolates with intermediate levels of resistance to penicillin and erythromycin-resistant isolates. The ketolides were more active than other macrolides and showed excellent activity against erythromycin-resistant strains. All the strains were inhibited by < or = 2 micrograms of HMR 3004/ml or by < or = 0.5 microgram of HMR 3647/ml.

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