Postantibiotic Effect of Trovafloxacin against Gram-Positive and -Negative Organisms | Zendy

Glenn A. Pankuch | Zendy; Michael R. Jacobs | Zendy; Peter C. Appelbaum | Zendy

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Postantibiotic Effect of Trovafloxacin against Gram-Positive and -Negative Organisms

Author(s) -

Glenn A. Pankuch,

Michael R. Jacobs,

Peter C. Appelbaum

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.6.1503

Subject(s) - trovafloxacin , pseudomonas aeruginosa , microbiology and biotechnology , minimum inhibitory concentration , escherichia coli , streptococcus pneumoniae , staphylococcus aureus , chemistry , antibacterial agent , antibiotics , biology , bacteria , biochemistry , genetics , gene

Trovafloxacin pneumococcal and staphylococcal postantibiotic effects (PAEs) were 0.7 to 1.8 and 0.7 to 2.4 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.4 to 4.4 h. Pneumococcal and staphylococcal postantibiotic sub-MIC effects (PA-SMEs) (0.4 times the MIC) were 2.3 to 3.7 and 2.4 to > 9.2 h, respectively, and E. coli PA-SMEs (0.3 times the MIC) were 6.8 to > 12.0 h. For one P. aeruginosa strain, the PA-SME (0.4 times the MIC) was > 10 h; in the other, rapid bactericidal activity precluded measurement.

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