Roxithromycin Inhibits Cytokine Production by and Neutrophil Attachment to Human Bronchial Epithelial Cells In Vitro | Zendy

Shin Kawasaki | Zendy; Hajime Takizawa | Zendy; Takayuki Ohtoshi | Zendy; Naonobu Takeuchi | Zendy; Tadashi Kohyama | Zendy; Hidenori Nakamura | Zendy; Tsuyoshi Kasama | Zendy; Kazuo Kobayashi | Zendy; Kazuhiko Nakahara | Zendy; Yutaka Morita | Zendy; Kazuhiko Yamamoto | Zendy

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Roxithromycin Inhibits Cytokine Production by and Neutrophil Attachment to Human Bronchial Epithelial Cells In Vitro

Author(s) -

Shin Kawasaki,

Hajime Takizawa,

Takayuki Ohtoshi,

Naonobu Takeuchi,

Tadashi Kohyama,

Hidenori Nakamura,

Tsuyoshi Kasama,

Kazuo Kobayashi,

Kazuhiko Nakahara,

Yutaka Morita,

Kazuhiko Yamamoto

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.6.1499

Subject(s) - roxithromycin , in vitro , cytokine , immunology , interleukin 8 , chemistry , microbiology and biotechnology , biology , biochemistry , antibiotics , erythromycin

We evaluated the effect of roxithromycin on cytokine production and neutrophil attachment to human airway epithelial cells. Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor. It inhibited neutrophil adhesion to epithelial cells. Roxithromycin modulates local recruitment and activation of inflammatory cells, which may have relevance to its efficacy in airway diseases.

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