Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases | Zendy

Takaaki Akasaka | Zendy; Seiko Kurosaka | Zendy; Yoko Uchida | Zendy; Mayumi Tanaka | Zendy; Kenichi Sato | Zendy; I Hayakawa | Zendy

Open Access

Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases

Author(s) -

Takaaki Akasaka,

Seiko Kurosaka,

Yoko Uchida,

Mayumi Tanaka,

Kenichi Sato,

I Hayakawa

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.5.1284

Subject(s) - topoisomerase , dna gyrase , topoisomerase iv , escherichia coli , topoisomerase inhibitor , minimum inhibitory concentration , biology , antibacterial agent , microbiology and biotechnology , staphylococcus aureus , bacteria , in vitro , chemistry , biochemistry , antibiotics , genetics , gene

The in vitro inhibitory effects of sitafloxacin (DU-6859a) and its three stereoisomers on bacterial DNA gyrase from Escherichia coli, topoisomerase IV from Staphylococcus aureus, and topoisomerase II from human placenta were compared. No correlation was observed between the inhibitory activities of quinolones against bacterial type II topoisomerases and those against human topoisomerase II. Sitafloxacin showed the most potent inhibitory activities against bacterial type II topoisomerases and the lowest activity against human type II topoisomerase.

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