Comparative Activities of Clinafloxacin against Gram-Positive and -Negative Bacteria | Zendy

Lois M. Ednie | Zendy; Michael R. Jacobs | Zendy; Peter C. Appelbaum | Zendy

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Comparative Activities of Clinafloxacin against Gram-Positive and -Negative Bacteria

Author(s) -

Lois M. Ednie,

Michael R. Jacobs,

Peter C. Appelbaum

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.5.1269

Subject(s) - trovafloxacin , microbiology and biotechnology , piperacillin , ciprofloxacin , sparfloxacin , imipenem , piperacillin/tazobactam , tazobactam , ceftazidime , antibacterial agent , agar dilution , biology , ofloxacin , antibiotics , minimum inhibitory concentration , bacteria , antibiotic resistance , genetics , pseudomonas aeruginosa

Activities of clinafloxacin, ciprofloxacin, levofloxacin, sparfloxacin, trovafloxacin, piperacillin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, ceftazidime, and imipenem against 354 ciprofloxacin-susceptible and -intermediate-resistant organisms were tested by agar dilution. Clinafloxacin yielded the lowest quinolone MICs (< or = 0.5 microg/ml against ciprofloxacin-susceptible organisms and < or = 16.0 microg/ml against ciprofloxacin-intermediate-resistant organisms) compared to those of levofloxacin, trovafloxacin, and sparfloxacin. Ceftazidime, piperacillin alone or combined with tazobactam, trimethoprim-sulfamethoxazole, and imipenem usually yielded higher MICs against ciprofloxacin-resistant strains.

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