Fluconazole Pharmacokinetics in Burn Patients | Zendy

Bradley A. Boucher | Zendy; Stephen R. King | Zendy; Heidi L. Wandschneider | Zendy; William L. Hickerson | Zendy; Scott D. Hanes | Zendy; Vanessa L. Herring | Zendy; Todd W. Canada | Zendy; Mary M. Hess | Zendy

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Fluconazole Pharmacokinetics in Burn Patients

Author(s) -

Bradley A. Boucher,

Stephen R. King,

Heidi L. Wandschneider,

William L. Hickerson,

Scott D. Hanes,

Vanessa L. Herring,

Todd W. Canada,

Mary M. Hess

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.4.930

Subject(s) - pharmacokinetics , volume of distribution , fluconazole , body surface area , total body surface area , medicine , half life , metabolic clearance rate , anesthesia , gastroenterology , antifungal , dermatology

The pharmacokinetics of fluconazole in nine adult patients with severe (30 to 95% total body surface area) burns were studied. There was no significant difference in half-life (t1/2), clearance (CL), or volume of distribution (V) over time in five patients on days 3 and 8 of the study (P > 0.05). Combined parameter estimates (means +/- standard deviations) for all nine patients for the two study periods were as follows: t1/2, 24.4 +/- 5.8 h; CL, 0.36 +/- 0.09 ml/min/kg; and V, 0.72 +/- 0.12 liters/kg. These estimates of t1/2 and CL in burn patients were approximately 13% shorter and 30% more rapid, respectively, than the most extreme estimates reported for other populations.

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