Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England | Zendy

J. Christophers | Zendy; Julie Clayton | Zendy; J. Craske | Zendy; Rosemary Ward | Zendy; Peter Collins | Zendy; M. Trowbridge | Zendy; G. Darby | Zendy

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Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England

Author(s) -

J. Christophers,

Julie Clayton,

J. Craske,

Rosemary Ward,

Peter Collins,

M. Trowbridge,

G. Darby

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.4.868

Subject(s) - herpes simplex virus , virology , varicella zoster virus , virus , medicine , herpesviridae , population , aciclovir , viral disease , biology , environmental health

Acyclovir (ACV) has been used for more than 15 years in the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) disease. The present survey was undertaken to assess the level of ACV resistance in the population. More than 2,000 HSV isolates from both immunocompetent and immunocompromised patients in northwest England were collected over a 2-year period and tested for sensitivity to ACV. These studies suggested a prevalence of resistance of approximately 0.1 to 0.6% in immunocompetent individuals, with no apparent difference in prevalence between treated and untreated groups. In line with previous studies, the prevalence of resistance in treated immunocompromised individuals was approximately 6%.

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