Activities of Isoniazid Alone and in Combination with Other Drugs against Mycobacterium avium Infection in Beige Mice | Zendy

Lanfranco Fattorini | Zendy; Xiao Yan | Zendy; Maurizio Mattei | Zendy; Yongjun Li | Zendy; Elisabetta Iona | Zendy; Maria Luisa Ricci | Zendy; Ove Fredrik Thoresen | Zendy; Roberta Creti | Zendy; Graziella Orefici | Zendy

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Activities of Isoniazid Alone and in Combination with Other Drugs against Mycobacterium avium Infection in Beige Mice

Author(s) -

Lanfranco Fattorini,

Xiao Yan,

Maurizio Mattei,

Yongjun Li,

Elisabetta Iona,

Maria Luisa Ricci,

Ove Fredrik Thoresen,

Roberta Creti,

Graziella Orefici

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.3.712

Subject(s) - isoniazid , amikacin , clarithromycin , microbiology and biotechnology , medicine , pharmacology , antibacterial agent , mycobacterium , antibiotics , biology , tuberculosis , pathology

Monotherapy with isoniazid or amikacin or clarithromycin or combinations of two of these drugs showed nil to modest therapeutic activity in beige mice infected with Mycobacterium avium. However, the combination of all three, isoniazid-amikacin-clarithromycin, markedly reduced CFUs in both spleens and lungs after 91 days of infection.

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