Antimicrobial Activity of Novel Furanonaphthoquinone Analogs | Zendy

Kumiko Nagata | Zendy; KeiIchi Hirai | Zendy; Junko Koyama | Zendy; Yasunao Wada | Zendy; Toshihide Tamura | Zendy

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Antimicrobial Activity of Novel Furanonaphthoquinone Analogs

Author(s) -

Kumiko Nagata,

KeiIchi Hirai,

Junko Koyama,

Yasunao Wada,

Toshihide Tamura

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.3.700

Subject(s) - antimicrobial , staphylococcus aureus , microbiology and biotechnology , bacteria , pathogenic bacteria , antibiotics , methicillin resistant staphylococcus aureus , biology , helicobacter pylori , genetics

Analogs of furanonaphthoquinone (FNQ) from Tecoma ipe Mart had MICs ranging from 1.56 to 25 microg/ml against gram-positive bacteria. FNQ showed significantly lower MICs against methicillin-resistant Staphylococcus aureus than against methicillin-sensitive S. aureus. FNQ inhibited Helicobacter pylori with an MIC of 0.1 microg/ml. Fungi, including pathogenic species, were sensitive to FNQ with MICs similar to those of amphotericin B.

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