Neurotoxicodynamics of the Interaction between Ciprofloxacin and Foscarnet in Mice | Zendy

Hirotami Matsuo | Zendy; Miwako Ryu | Zendy; Aya Nagata | Zendy; Takahiro Uchida | Zendy; Junichi Kawakami | Zendy; Koujirou Yamamoto | Zendy; Tatsuji Iga | Zendy; Yasufumi Sawada | Zendy

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Neurotoxicodynamics of the Interaction between Ciprofloxacin and Foscarnet in Mice

Author(s) -

Hirotami Matsuo,

Miwako Ryu,

Aya Nagata,

Takahiro Uchida,

Junichi Kawakami,

Koujirou Yamamoto,

Tatsuji Iga,

Yasufumi Sawada

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.3.691

Subject(s) - ciprofloxacin , foscarnet , pharmacology , drug interaction , pharmacokinetic interaction , chemistry , antibiotics , medicine , pharmacokinetics , biochemistry , ganciclovir , human cytomegalovirus , gene

The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of gamma-aminobutyric acid (GABA)-GABA(A) receptor binding in the presence of PFA.

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