In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine | Zendy

Olivier Domarle | Zendy; Guillaume Blampain | Zendy; Huguette Agnaniet | Zendy; T. Nzadiyabi | Zendy; Jacques Lébibi | Zendy; Jacques Brocard | Zendy; Lucien Maciejewski | Zendy; Christophe Biot | Zendy; Arthur Georges | Zendy; Pascal Millet | Zendy

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In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine

Author(s) -

Olivier Domarle,

Guillaume Blampain,

Huguette Agnaniet,

T. Nzadiyabi,

Jacques Lébibi,

Jacques Brocard,

Lucien Maciejewski,

Christophe Biot,

Arthur Georges,

Pascal Millet

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.3.540

Subject(s) - chloroquine , plasmodium falciparum , ferrocene , in vitro , pharmacology , chemistry , antimalarial agent , stereochemistry , biochemistry , biology , combinatorial chemistry , malaria , immunology , electrode , electrochemistry

The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adapted Plasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chloroquine-resistant parasites. This compound, associated with tartaric acid for better solubility, was highly effective. The role of the ferrocene in reversing chloroquine resistance is discussed, as is its potential use for human therapy.

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