QacA Multidrug Efflux Pump from Staphylococcus aureus : Comparative Analysis of Resistance to Diamidines, Biguanidines, and Guanylhydrazones | Zendy

Bernadette A. Mitchell | Zendy; Melissa H. Brown | Zendy; Ronald A. Skurray | Zendy

Open Access

QacA Multidrug Efflux Pump from Staphylococcus aureus : Comparative Analysis of Resistance to Diamidines, Biguanidines, and Guanylhydrazones

Author(s) -

Bernadette A. Mitchell,

Melissa H. Brown,

Ronald A. Skurray

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.2.475

Subject(s) - efflux , staphylococcus aureus , multiple drug resistance , microbiology and biotechnology , antimicrobial , antibiotics , biology , chemistry , bacteria , biochemistry , genetics

The staphylococcal multidrug efflux pump QacA mediates resistance to a broad spectrum of monovalent and divalent antimicrobial cations. Resistance toward various classes of these compounds identified features of the substrate that may be important for interaction with QacA. Analysis of combinations of two substrates suggested that the same mechanism is used for the extrusion of different classes of compounds.

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