In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide | Zendy

Michael H. Cynamon | Zendy; Robert J. Speirs | Zendy; John T. Welch | Zendy

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In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide

Author(s) -

Michael H. Cynamon,

Robert J. Speirs,

John T. Welch

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.2.462

Subject(s) - antimycobacterial , pyrazinamide , microbiology and biotechnology , mycobacterium bovis , in vitro , mycobacterium tuberculosis , antibacterial agent , mycobacterium , tuberculosis , chemistry , nontuberculous mycobacteria , pharmacology , biology , antibiotics , medicine , rifampicin , biochemistry , pathology

5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.

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