Effects of Aluminum Hydroxide and Famotidine on Bioavailability of Tosufloxacin in Healthy Volunteers | Zendy

Rumiko Minami | Zendy; Chizuko Nakamura | Zendy; Nobuo Inotsume | Zendy; Masahiro Nakano | Zendy

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Effects of Aluminum Hydroxide and Famotidine on Bioavailability of Tosufloxacin in Healthy Volunteers

Author(s) -

Rumiko Minami,

Chizuko Nakamura,

Nobuo Inotsume,

Masahiro Nakano

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.2.453

Subject(s) - bioavailability , famotidine , hydroxide , chemistry , pharmacology , medicine , inorganic chemistry

This study was designed to determine the influence of aluminum hydroxide and famotidine on the bioavailability of tosufloxacin. Coadministration of aluminum hydroxide reduced the bioavailability of tosufloxacin by 31.6% (P < 0.05). Famotidine did not alter tosufloxacin absorption. To avoid potential treatment failures, the concurrent use of tosufloxacin and aluminum hydroxide should be avoided altogether.

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