Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV Associated with Quinolone Resistance in Enterococcus faecalis | Zendy

Emiko Kanematsu | Zendy; Takashi Deguchi | Zendy; Mitsuru Yasuda | Zendy; Takeshi Kawamura | Zendy; Yoshinori Nishino | Zendy; Yukimichi Kawada | Zendy

Open Access

Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV Associated with Quinolone Resistance in Enterococcus faecalis

Author(s) -

Emiko Kanematsu,

Takashi Deguchi,

Mitsuru Yasuda,

Takeshi Kawamura,

Yoshinori Nishino,

Yukimichi Kawada

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.2.433

Subject(s) - dna gyrase , enterococcus faecalis , topoisomerase iv , quinolone , biology , microbiology and biotechnology , topoisomerase , protein subunit , antibacterial agent , dna , gene , genetics , escherichia coli , antibiotics

The gyrA and parC genes of 31 clinical isolates of Enterococcus faecalis, including fluoroquinolone-resistant isolates, were partially sequenced and analyzed for target alterations. Topoisomerase IV may be a primary target in E. faecalis, but high-level fluoroquinolone resistance was associated with simultaneous alterations in both GyrA and ParC.

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