KY-62, a Polyene Analog of Amphotericin B, for Treatment of Murine Candidiasis | Zendy

John R. Graybill | Zendy; Laura K. Najvar | Zendy; Annette W. Fothergill | Zendy; Thomas C. Hardin | Zendy; Michael G. Rinaldi | Zendy; C. Lambros | Zendy; Steven L. Regen | Zendy

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KY-62, a Polyene Analog of Amphotericin B, for Treatment of Murine Candidiasis

Author(s) -

John R. Graybill,

Laura K. Najvar,

Annette W. Fothergill,

Thomas C. Hardin,

Michael G. Rinaldi,

C. Lambros,

Steven L. Regen

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.1.147

Subject(s) - amphotericin b , potency , candida albicans , in vivo , pharmacology , flucytosine , polyene , antibiotics , in vitro , medicine , biology , microbiology and biotechnology , antifungal , biochemistry

KY-62 is a water-soluble analog of amphotericin B. In vitro testing of five clinical isolates of Candida albicans showed KY-62 to have potency similar to that of amphotericin B. KY-62 was administered to mice infected intravenously with C. albicans. In vivo, KY-62 was effective in immunocompetent mice, with potency similar to that of amphotericin B. KY-62 was well tolerated up to 30 mg/kg of body weight per dose, an amount that would be lethal with amphotericin B. KY-62 was less effective in mice rendered neutropenic with 5-fluorouracil. The addition of flucytosine had little effect. KY-62 may have potential for clinical development.

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