Adaptive mutations produce resistance to ciprofloxacin | Zendy

Christian S. Riesenfeld | Zendy; M Everett | Zendy; Laura J. V. Piddock | Zendy; B G Hall | Zendy

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Adaptive mutations produce resistance to ciprofloxacin

Author(s) -

Christian S. Riesenfeld,

M Everett,

Laura J. V. Piddock,

B G Hall

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.9.2059

Subject(s) - ciprofloxacin , biology , microbiology and biotechnology , escherichia coli , mutation , phenotype , adaptive mutation , enterobacteriaceae , genetics , strain (injury) , gene , antibiotics , medicine , population , environmental health , anatomy

Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.

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