Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis | Zendy

C L Kelley | Zendy; D A Rouse | Zendy; S L Morris | Zendy

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Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis

Author(s) -

C L Kelley,

D A Rouse,

S L Morris

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.9.2057

Subject(s) - isoniazid , mycobacterium tuberculosis , biology , gene , microbiology and biotechnology , mutant , tuberculosis , mutation , virology , mycobacterium , genetics , bacteria , medicine , pathology

The ahpC genes of 57 clinical isolates and one in vitro mutant of Mycobacterium tuberculosis were evaluated by nucleotide sequence analyses. Although compensatory ahpC promoter mutations were identified in 8 catalase-negative, katG-defective strains, the ahpC genes of 25 catalase-positive, isoniazid-resistant isolates and 25 drug-sensitive strains were not altered.

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