Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group | Zendy

Matthew E. Falagas | Zendy; L. A. McDermott | Zendy; David R. Snydman | Zendy

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Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group

Author(s) -

Matthew E. Falagas,

L. A. McDermott,

David R. Snydman

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.9.2047

Subject(s) - bacteroides fragilis , imipenem , trovafloxacin , piperacillin , microbiology and biotechnology , clindamycin , sulbactam , meropenem , ampicillin , antibiotics , ciprofloxacin , antimicrobial , chemistry , in vitro , biology , bacteria , biochemistry , antibiotic resistance , genetics , pseudomonas aeruginosa

We studied the effect of pH (7.1, 6.3, and 5.8) on the in vitro susceptibilities of 59 isolates of Bacteroides fragilis and 60 isolates of other B. fragilis group species to trovafloxacin, ciprofloxacin, clindamycin, ampicillin-sulbactam, piperacillin-tazobactam, imipenem, and meropenem. For each agent tested the geometric mean MIC was highest at pH 5.8, intermediate at pH 6.3, and lowest at pH 7.1. The magnitude of the pH effect varied greatly among different antibiotics. These data show that an acidic pH decreases the in vitro susceptibilities of the B. fragilis group to several antibiotics.

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