Penicillin-binding proteins and induction of AmpC beta-lactamase | Zendy

Christine C. Sanders | Zendy; Patricia A. Bradford | Zendy; Anton F. Ehrhardt | Zendy; Karen Bush | Zendy; Kevin D. Young | Zendy; Thomas A. Henderson | Zendy; William E. Sanders | Zendy

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Penicillin-binding proteins and induction of AmpC beta-lactamase

Author(s) -

Christine C. Sanders,

Patricia A. Bradford,

Anton F. Ehrhardt,

Karen Bush,

Kevin D. Young,

Thomas A. Henderson,

William E. Sanders

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.9.2013

Subject(s) - penicillin binding proteins , penicillin , microbiology and biotechnology , beta lactamase inhibitors , beta lactamase , antibiotics , chemistry , biology , biochemistry , escherichia coli , gene

In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lactamase, there is probably a redundancy in function among the different PBPs.

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