Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B | Zendy

Neelufar Mozaffarian | Zendy; Joan W. Berman | Zendy; A. Casadevall | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B

Author(s) -

Neelufar Mozaffarian,

Joan W. Berman,

A. Casadevall

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.8.1825

Subject(s) - cryptococcus neoformans , amphotericin b , nitrite , nitric oxide , microbiology and biotechnology , virulence factor , macrophage , mechanism of action , virulence , polysaccharide , phagocytosis , antibiotics , chemistry , interferon gamma , cytokine , biology , immunology , antifungal , biochemistry , in vitro , nitrate , organic chemistry , gene

Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage-like J774.16 cells in a dose-dependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable to elicit nitrite, with or without AmB.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research