In vitro activity of Bay 12-8039, a new 8-methoxyquinolone | Zendy

Robert J. Fass | Zendy

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In vitro activity of Bay 12-8039, a new 8-methoxyquinolone

Author(s) -

Robert J. Fass

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.8.1818

Subject(s) - ofloxacin , ciprofloxacin , bay , pseudomonas aeruginosa , microbiology and biotechnology , biology , enterobacteriaceae , quinolone , antibiotics , bacteria , escherichia coli , geography , biochemistry , genetics , archaeology , gene

MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-fold more active than ciproiloxacin and ofloxacin against nonfermenters (except P. aeruginosa), staphylococci, streptococci, enterococci, and anaerobes. As determined by regression analysis, there was a high degree of correlation among quinolone MICs.

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