Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa | Zendy

Walter Haas | Zendy; K Schilke | Zendy; Jeannette Brand | Zendy; Beate Amthor | Zendy; Karin Weyer | Zendy; P. Bernard Fourie | Zendy; Gisela Bretzel | Zendy; V. Sticht-Groh | Zendy; H. J. Bremer | Zendy

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Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa

Author(s) -

Walter Haas,

K Schilke,

Jeannette Brand,

Beate Amthor,

Karin Weyer,

P. Bernard Fourie,

Gisela Bretzel,

V. Sticht-Groh,

H. J. Bremer

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.7.1601

Subject(s) - mycobacterium tuberculosis , biology , genetics , gene , isoniazid , point mutation , restriction fragment length polymorphism , sequence analysis , genome , start codon , tuberculosis , microbiology and biotechnology , mutation , polymerase chain reaction , base sequence , medicine , pathology

A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.

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