In vivo and in vitro antiplasmodial activities of some plants traditionally used in Guatemala against malaria | Zendy

Frits Franssen | Zendy; L J Smeijsters | Zendy; Isabella Berger | Zendy; Bryan Aldana | Zendy

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In vivo and in vitro antiplasmodial activities of some plants traditionally used in Guatemala against malaria

Author(s) -

Frits Franssen,

L J Smeijsters,

Isabella Berger,

Bryan Aldana

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.7.1500

Subject(s) - brine shrimp , artemia salina , plasmodium berghei , plasmodium falciparum , biology , traditional medicine , in vivo , in vitro , malaria , botany , chemistry , toxicity , biochemistry , microbiology and biotechnology , medicine , immunology , organic chemistry

We present an evaluation of the antiplasmodial and cytotoxic effects of four plants commonly used in Guatemalan folk medicine against malaria. Methanol extracts of Simarouba glauca D. C., Sansevieria guineensis Willd, Croton guatemalensis Lotsy, and Neurolaena lobata (L.)R.Br. significantly reduced parasitemias in Plasmodium berghei-infected mice. Dichloromethane fractions were screened for their cytotoxicities on Artemia salina (brine shrimp) larvae, and 50% inhibitory concentrations were determined for Plasmodium falciparum in in vitro cultures. Both chloroquine-susceptible and -resistant strains of P. falciparum were significantly inhibited by these extracts. Of all dichloromethane extracts, only the S. glauca cortex extract was considered to be toxic to nauplii of A. salina in the brine shrimp test.

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