Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae | Zendy

Erdoğan Memili | Zendy; Bernard Weisblum | Zendy

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Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae

Author(s) -

Erdoğan Memili,

Bernard Weisblum

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.5.1203

Subject(s) - streptomyces fradiae , tylosin , biology , mutant , microbiology and biotechnology , streptomyces , antibiotics , biochemistry , actinomycetales , bacteria , genetics , gene

We compared ermSF induction in wild-type Streptomyces fradiae NRRL B-2702 and that in GS-14, a tylA mutant which cannot synthesize tylosin. Our findings suggest that (i) endogenously synthesized tylosin plays an obligatory role in ermSF induction and (ii) tylosin, or a biosynthetic intermediate beyond tylactone, has an "autocrine" function that induces ErmSF synthesis, thereby enabling S. fradiae to resist higher levels of tylosin.

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