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The activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against bite wound isolates were determined by the agar dilution method. DU-6859a was the most active compound (MICs, &lt; or = 0.125 microg/ml) against all Pasteurella species, Staphylococcus aureus, and streptococci; anaerobes were susceptible to &lt; or = 0.5 microg/ml, except fusobacteria, which were susceptible to &lt; or = 2 microg/ml. Against aerobes, levofloxacin was more active than ofloxacin (MIC at which 90% of isolates are inhibited [MIC90], &lt; or = 1.0 microg/ml for both) and sparfloxacin and ciprofloxacin were also active (MIC90s, &lt; or = 0.25 and &lt; 1 microg/ml, respectively).

antimicrobial agents and chemotherapy

Comparative in vitro activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against 387 aerobic and anaerobic bite wound isolates