Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae | Zendy

Young Sam Kim | Zendy; Qian Liu | Zendy; Lucian Chow | Zendy; Martin G. Täuber | Zendy

Open Access

Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae

Author(s) -

Young Sam Kim,

Qian Liu,

Lucian Chow,

Martin G. Täuber

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.5.1186

Subject(s) - trovafloxacin , streptococcus pneumoniae , penicillin , microbiology and biotechnology , ampicillin , meningitis , antibacterial agent , antibiotics , chemistry , medicine , biology , surgery

The fluoroquinolone trovafloxacin was bactericidal (0.47 +/- 0.23 delta log10 CFU/ml x h after 10 mg/kg of body weight and 0.78 +/- 0.15 delta log10 CFU/ml x h after 30 mg/kg) in the treatment of experimental meningitis caused by a highly penicillin-resistant (MIC and minimum bactericidal concentration = 4 and 4 microg/ml) strain of Streptococcus pneumoniae. Combinations with ampicillin and rifampin were indifferent compared to single drugs.

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