Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants | Zendy

Manuel Hidalgo | Zendy; Javier Hornedo | Zendy; Carlos Lumbreras | Zendy; José Trigo | Zendy; C. Gómez | Zendy; Sofía Perea | Zendy; Ana RuizCasado | Zendy; Ricardo Hitt | Zendy; H. Cortés-Funes | Zendy

Open Access

Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants

Author(s) -

Manuel Hidalgo,

Javier Hornedo,

Carlos Lumbreras,

José Trigo,

C. Gómez,

Sofía Perea,

Ana RuizCasado,

Ricardo Hitt,

H. Cortés-Funes

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.5.1175

Subject(s) - ciprofloxacin , medicine , incidence (geometry) , bacteremia , chemotherapy , regimen , surgery , transplantation , antibacterial agent , antibiotics , gastroenterology , microbiology and biotechnology , biology , physics , optics

We compared ciprofloxacin alone with ciprofloxacin plus rifampin (C + R) as a prophylactic antibacterial regimen for 40 patients with solid tumors treated with high-dose chemotherapy and autologous stem cell transplantation support. No differences were found between groups in the time elapsed to the onset of fever, incidence of febrile episodes, amphotericin B use, and length of hospital stay. However, C + R combination prophylaxis significantly reduced the incidence of gram-positive bacteremia (five versus zero episodes) but was associated with a higher incidence of drug-related side effects.

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