Comparative activities of amikacin against Mycobacterium avium complex in nude and beige mice | Zendy

Nacer Lounis | Zendy; Botao Ji | Zendy; C. Truffot-Pernot | Zendy; J Grosset | Zendy

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Comparative activities of amikacin against Mycobacterium avium complex in nude and beige mice

Author(s) -

Nacer Lounis,

Botao Ji,

C. Truffot-Pernot,

J Grosset

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.5.1168

Subject(s) - amikacin , clarithromycin , nude mouse , antimicrobial , ratón , mycobacterium avium complex , microbiology and biotechnology , biology , chemotherapy , pharmacology , antibiotics , immunology , cell culture , genetics

After 4 weeks of treatment, clarithromycin (CLAR) and amikacin showed similar antimicrobial activities against the Mycobacterium avium complex in mice. There was a difference, however, in the effectiveness of the drugs in different types of mice: both drugs displayed bactericidal effects in beige mice but only bacteriostatic effects in nude mice. Because the effectiveness of CLAR is less in nude mice than in beige mice, the predictive value of the nude mouse model for the efficacy of chemotherapy is less than that of the beige mouse model.

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