In vitro activity of a new echinocandin, LY303366, compared with those of amphotericin B and fluconazole against clinical yeast isolates | Zendy

Ömrüm Uzun | Zendy; Sesin Kocagöz | Zendy; Yeşim Çetinkaya | Zendy; S. Arıkan | Zendy; Serhat Ünal | Zendy

Open Access

In vitro activity of a new echinocandin, LY303366, compared with those of amphotericin B and fluconazole against clinical yeast isolates

Author(s) -

Ömrüm Uzun,

Sesin Kocagöz,

Yeşim Çetinkaya,

S. Arıkan,

Serhat Ünal

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.5.1156

Subject(s) - echinocandin , microbiology and biotechnology , candida krusei , candida glabrata , fluconazole , broth microdilution , biology , amphotericin b , candida parapsilosis , candida tropicalis , candida albicans , fungi imperfecti , in vitro , yeast , minimum inhibitory concentration , antibiotics , antifungal , biochemistry

The in vitro activity of LY303366, a new echinocandin derivative, was evaluated with 191 yeast isolates by a broth microdilution method. The MICs at which 50% of the isolates were inhibited were 0.125 microg/ml for Candida albicans and C. tropicalis, 0.25 microg/ml for C. krusei, C. kefyr, and C. glabrata, and 2.0 microg/ml for C. parapsilosis.

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