Early effects of ganciclovir therapy on the quantity of cytomegalovirus DNA in leukocytes of immunocompromised patients | Zendy

Guy Boivin | Zendy; Mary Quirk | Zendy; Barbara A. Kringstad | Zendy; Max Germain | Zendy; M C Jordan | Zendy

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Early effects of ganciclovir therapy on the quantity of cytomegalovirus DNA in leukocytes of immunocompromised patients

Author(s) -

Guy Boivin,

Mary Quirk,

Barbara A. Kringstad,

Max Germain,

M C Jordan

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.4.860

Subject(s) - ganciclovir , cytomegalovirus , betaherpesvirinae , immunology , medicine , virology , herpesviridae , viral load , human cytomegalovirus , cytomegalovirus infection , foscarnet , viral disease , virus

The cytomegalovirus (CMV) DNA load in leukocytes was measured in 26 immunocompromised patients with CMV disease before and after 10 days of intravenous ganciclovir therapy. Before therapy, the circulating DNA burden of bone marrow transplant recipients was significantly lower than that of other transplant or AIDS patients. Ganciclovir induction therapy significantly decreased the viral DNA load in the leukocyte populations of most patients.

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