Conservation of the multidrug resistance efflux gene oprM in Pseudomonas aeruginosa | Zendy

Nicole R. Bianco | Zendy; Shádi Neshat | Zendy; Keith Poole | Zendy

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Conservation of the multidrug resistance efflux gene oprM in Pseudomonas aeruginosa

Author(s) -

Nicole R. Bianco,

Shádi Neshat,

Keith Poole

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.4.853

Subject(s) - efflux , pseudomonas aeruginosa , microbiology and biotechnology , biology , pseudomonas chlororaphis , multiple drug resistance , pseudomonas , pseudomonas putida , pseudomonadales , pseudomonadaceae , genomic island , genomic dna , gene , genetics , drug resistance , bacteria , genome

An intragenic probe derived from the multidrug resistance gene oprM hybridized with genomic DNA from all 20 serotypes of Pseudomonas aeruginosa and from all 34 environmental and clinical isolates tested, indicating that the MexA-MexB-OprM multidrug efflux system is highly conserved in this organism. The oprM probe also hybridized with genomic DNA from Pseudomonas aureofaciens, Pseudomonas chlororaphis, Pseudomonas syringae, Burkholderia pseudomallei, and Pseudomonas putida, suggesting that efflux-mediated multidrug resistance mechanisms may be somewhat broadly distributed.

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