Direct evidence for uptake of intact liposomes encapsulating silver sulfadiazine by cultured human keratinocytes based on combined transmission electron microscopy and X-ray microanalysis | Zendy

Martin Schaller | Zendy; Rainer Wurm | Zendy; H.C. Korting | Zendy

Open Access

Direct evidence for uptake of intact liposomes encapsulating silver sulfadiazine by cultured human keratinocytes based on combined transmission electron microscopy and X-ray microanalysis

Author(s) -

Martin Schaller,

Rainer Wurm,

H.C. Korting

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.3.717

Subject(s) - silver sulfadiazine , transmission electron microscopy , phagocytosis , microanalysis , electron microscope , liposome , sulfadiazine , chemistry , microscopy , nuclear chemistry , materials science , microbiology and biotechnology , biology , nanotechnology , biochemistry , immunology , pathology , antibiotics , medicine , optics , organic chemistry , physics , wound healing

Cultured human keratinocytes were exposed to liposomally encapsulated silver sulfadiazine, free silver sulfadiazine, silver sulfadiazine cream, and a corresponding vehicle for 5 min to 24 h. Phagocytosis of intact liposomes by keratinocytes was demonstrated in vitro by combined X-ray microanalysis and electron microscopy. Silver as an active part of the antimicrobial served as an electron-dense marker.

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