Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis | Zendy

Tânia Luna | Zendy; R. Mazzolla | Zendy; Gabriella Romanò | Zendy; Elisabetta Blasi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis

Author(s) -

Tânia Luna,

R. Mazzolla,

Gabriella Romanò,

Elisabetta Blasi

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.3.706

Subject(s) - cryptococcosis , amphotericin b , in vivo , in vitro , meningoencephalitis , cryptococcus neoformans , biology , microbiology and biotechnology , antifungal , immunology , virology , pharmacology , biochemistry , genetics

A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research