Transferable hyperproduction of TEM-1 beta-lactamase in Shigella flexneri due to a point mutation in the pribnow box | Zendy

L. Kristopher Siu | Zendy; PakLeung Ho | Zendy; KwokYung Yuen | Zendy; S S Wong | Zendy; P. Y. Chau | Zendy

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Transferable hyperproduction of TEM-1 beta-lactamase in Shigella flexneri due to a point mutation in the pribnow box

Author(s) -

L. Kristopher Siu,

PakLeung Ho,

KwokYung Yuen,

S S Wong,

P. Y. Chau

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.2.468

Subject(s) - shigella flexneri , point mutation , microbiology and biotechnology , mutation , beta lactamase , beta (programming language) , shigella , biology , genetics , virology , bacteria , escherichia coli , computer science , gene , salmonella , programming language

TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied. In both strains the blaTEM gene was encoded as a single copy on a large conjugatively transferable plasmid. A single G-->T transversion at position 1 of the -10 consensus sequence was identified to be the mechanism of TEM-1 hyperproduction.

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