Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci | Zendy

M C Moken | Zendy; Laura M. McMurry | Zendy; Stuart B. Levy | Zendy

Open Access

Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci

Author(s) -

M C Moken,

Laura M. McMurry,

Stuart B. Levy

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.12.2770

Subject(s) - nalidixic acid , efflux , disinfectant , tetracycline , escherichia coli , biology , microbiology and biotechnology , mutant , chloramphenicol , antibiotics , multiple drug resistance , antibiotic resistance , gene , chemistry , genetics , organic chemistry

Mutants of Escherichia coli selected for resistance to the disinfectant pine oil or to a household product containing pine oil also showed resistance to multiple antibiotics (tetracycline, ampicillin, chloramphenicol, and nalidixic acid) and overexpressed the marA gene. Likewise, antibiotic-selected Mar mutants, which also overexpress marA, were resistant to pine oil. Deletion of the mar or acrAB locus, the latter encoding a multidrug efflux pump positively regulated in part by MarA, increased the susceptibility of wild-type and mutant strains to pine oil.

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