Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244 | Zendy

Laurent Bret | Zendy; El Bachir Chaibi | Zendy; C Chanal-Claris | Zendy; D. Sirot | Zendy; Roger Labia | Zendy; J. Sirot | Zendy

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Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244

Author(s) -

Laurent Bret,

El Bachir Chaibi,

C Chanal-Claris,

D. Sirot,

Roger Labia,

J. Sirot

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.11.2547

Subject(s) - escherichia coli , mutant , peptide sequence , beta lactamase , sequence (biology) , biology , enterobacteriaceae , gene , chemistry , genetics , microbiology and biotechnology

A novel inhibitor-resistant TEM (IRT) beta-lactamase was detected in an Escherichia coli isolate resistant to amoxicillin-clavulanate and susceptible to cephalothin. The substrate and inhibitor profiles of this beta-lactamase were similar to those of IRT-1 and IRT-2. The novel IRT's bla gene was sequenced, and the deduced amino acid sequence showed the amino acid replacement Arg for His-244 of the TEM-1 sequence. Substitutions for Arg-244 have been reported in three TEM-1 mutants: IRT-1 (which corresponds to TEM-31) (Cys), IRT-2/TEM-30 (Ser), and TEM-41 (Thr). We designated this novel beta-lactamase, which corresponds to TEM-51, IRT-15.

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