Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins | Zendy

Takashi Deguchi | Zendy; Mitsuru Yasuda | Zendy; KawamuraT | Zendy; Masahiro Nakano | Zendy; S Ozeki | Zendy; Emiko Kanematsu | Zendy; Yoshinori Nishino | Zendy; Yukimichi Kawada | Zendy

Open Access

Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins

Author(s) -

Takashi Deguchi,

Mitsuru Yasuda,

KawamuraT,

Masahiro Nakano,

S Ozeki,

Emiko Kanematsu,

Yoshinori Nishino,

Yukimichi Kawada

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.11.2544

Subject(s) - enterobacter cloacae , klebsiella pneumoniae , microbiology and biotechnology , enterobacteriaceae , quinolone , biology , antimicrobial , antibacterial agent , enterobacter , antibiotics , escherichia coli , gene , biochemistry

MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumoniae isolates and 21 Enterobacter cloacae isolates with altered GyrA or altered GyrA and ParC ranged from < or =0.025 to 6.25 microg/ml and from 0.1 to 3.13 microg/ml, respectively. Based on the MICs at which 90% of the isolates were inhibited for these strains of K. pneumoniae and E. cloacae, DU-6859a exhibited 16- to 256-fold-greater activity than currently available fluoroquinolones.

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