Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa | Zendy

Thilo Köhler | Zendy; M. Michéa-Hamzehpour | Zendy; Patrick Plésiat | Zendy; Anneliese Kahr | Zendy; J. C. Pechèré | Zendy

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Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa

Author(s) -

Thilo Köhler,

M. Michéa-Hamzehpour,

Patrick Plésiat,

Anneliese Kahr,

J. C. Pechèré

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.11.2540

Subject(s) - efflux , pseudomonas aeruginosa , microbiology and biotechnology , multiple drug resistance , pseudomonadales , biology , chemistry , drug resistance , bacteria , biochemistry , genetics

Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.

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