Quinolone susceptibility of norA-disrupted Staphylococcus aureus | Zendy

Hiroshi Yamada | Zendy; S Kurose-Hamada | Zendy; Yoshiko Fukuda | Zendy; Junichi Mitsuyama | Zendy; Masahiro Takahata | Zendy; Shinji Minami | Zendy; Yasuo Watanabe | Zendy; Hiroshi Narita | Zendy

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Quinolone susceptibility of norA-disrupted Staphylococcus aureus

Author(s) -

Hiroshi Yamada,

S Kurose-Hamada,

Yoshiko Fukuda,

Junichi Mitsuyama,

Masahiro Takahata,

Shinji Minami,

Yasuo Watanabe,

Hiroshi Narita

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.10.2308

Subject(s) - staphylococcus aureus , norfloxacin , quinolone , microbiology and biotechnology , antibacterial agent , antibiotics , mutant , biology , chemistry , bacteria , ciprofloxacin , genetics , gene

The MIC of norfloxacin for the norA-disrupted mutant termed RDN1, obtained from quinolone-susceptible Staphylococcus aureus RN4220, was eightfold lower than that for RN4220. The increase in susceptibility was related to an increase of drug accumulation by RDN1. These results indicate that NorA plays an important role in the susceptibility of quinolone-susceptible S. aureus to selected quinolones.

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